Umumi

Paracetamol Uşaq Dozası Nə Qədər Olmalıdır?

Parasetamol (asetaminofen və ya para -hidroksiasetanilid) qızdırma və yüngül və orta dərəcəli ağrıları müalicə etmək üçün istifadə edilən qeyri-opioid analjezik və qızdırmasalıcı agentdir. Bu, reseptsiz satılan ümumi bir dərmandır və ümumi marka adlarına Tylenol və Panadol daxildir.

Standart dozada parasetamol bədən istiliyini yalnız bir qədər azaldır. Parasetamol kəskin yüngül miqrendə ağrıları aradan qaldıra bilər, lakin epizodik gərginlik tipli baş ağrılarında yalnız yüngül relyef təmin edir. Parasetamol əməliyyatdan sonrakı ağrılarda da təsirlidir. Qısa müddətdə parasetamol göstərişlərə uyğun istifadə edildikdə təhlükəsiz və effektivdir.

Paracetamol Uşaqlar üçün Necə və Nə üçün İstifadə olunur?

Uşaqlarda yüngül və orta dərəcəli ağrıların və qızdırmaların simptomatik müalicəsi üçün göstərilir.

3 aydan kiçik uşaqlar: 2-ci ayda peyvənddən sonra qızdırması olan körpələr üçün 2,5 ml (1/2 qaşıq) doza uyğun gəlir. İki aydan kiçik körpələrdə istifadə edilməməlidir.
Bu pediatrik dozalar gündə 4 dəfə təkrarlana bilər, hər doza arasında 4 saat və ya daha çox vaxt qalır.
Maksimum gündəlik doza 10-15 mq/kq bölünmüş dozalarda 60 mq/kq təşkil edir.

Körpələrə Doza Miqdarı


3-6 aylıq körpələrdə 2.5 ml 6 saatda bir
6-24 aylıq körpələrdə 5 ml 6 saatda bir
2-4 aylıq körpələrdə 7.5 ml 6 saatda bir
4-6 aylıq körpələrdə 10 ml 6 saatda bir

Xüsusi istifadə xəbərdarlıqları və ehtiyat tədbirləri

Anemiya, ağciyər, qaraciyər və böyrək funksiyası pozulmuş xəstələrdə həkim nəzarəti altında ehtiyatla istifadə edilməlidir. Əvvəllər qaraciyər xəstəliyi olan xəstələr üçün, yüksək dozada və ya uzunmüddətli terapiya zamanı vaxtaşırı
Qaraciyər funksiyası testləri lazım ola bilər. Böyrək çatışmazlığı halında (kreatinin klirensi < 10 ml/dəq) həkim parasetamolun istifadəsinin fayda/risk nisbətini diqqətlə qiymətləndirməlidir.
Parasetamoldan ilk dəfə istifadə edən və ya əvvəllər istifadə etmiş şəxslərdə ilk doza və ya təkrar istifadə dozaları zamanı dəri qızartıları, səpgilər və ya dəri reaksiyaları baş verə bilər. Bu vəziyyətdə həkimə müraciət etmək, dərmandan istifadəni dayandırmaq və alternativ müalicəyə keçmək lazımdır. Parasetamol ilə dəri reaksiyası olan şəxs bu dərmanı və ya tərkibində parasetamol olan hər hansı digər dərmanı təkrar istifadə etməməlidir. Bu vəziyyətə Stiven Conson Sindromu (SJS), zəhərli epidermal nekroliz (TEN) kimi ciddi və potensial ölümcül şərtlər daxildir.
Kəskin ümumiləşdirilmiş ekzantematöz püstüloz (AGEP) daxil olmaqla dəri reaksiyalarına səbəb ola bilər.
Doza düzəliş edilməli və xəstə davamlı olaraq monitorinq edilməlidir.
Xroniki istifadədə gündəlik dozalarda və kəskin yüksək dozalarda qaraciyərin zədələnməsinə səbəb ola bilər.

Hamiləlik dövründə Paracetamolun istifadəsi

Hamiləlik dövründə A-PER-in təhlükəsizliyi müəyyən edilməmişdir. Parasetamol plasentadan keçir və ana konsentrasiyasına bənzər bir fetal konsentrasiyaya çatır. Bununla belə, insan hamiləliyində parasetamolun təhlükəsizliyinə dair epidemioloji sübutlar mövcuddur.
Məsələn, gələcək ananın parasetamolun qısa müddətli istifadəsi teratogen təsir göstərməmişdir.
Parasetamolun hamiləlik dövründə məruz qalması ilə bağlı adekvat klinik məlumat yoxdur.
Heyvan tədqiqatları hamiləlik/embrion/dölün inkişafı/doğuş və ya postnatal inkişafla bağlı birbaşa və ya dolayı zərərli təsirləri göstərmir.

Laktasiya dövrü Paracetamolun istifadəsi

Parasetamol ana südünə keçir (650 mq oral qəbulun 1%-dən az). Bununla belə, ana südü ilə qidalanan ana tərəfindən terapevtik dozalarda istifadənin körpə üçün risk yaratması gözlənilmir.

Farmakodinamik xassələri

Farmakoterapevtik qrupu: Analjeziklər
ATC kodu: N02BE01

Parasetamol analjezik və antipiretikdir. Parasetamolun terapevtik təsirinin siklooksigenaza fermentinin inhibəsi nəticəsində prostaglandin sintezinin ləngiməsi ilə əlaqədar olduğu düşünülür.

Parasetamolun periferik siklooksigenaza nisbətən mərkəzi siklooksigenaza təsiri:
Onun siklooksigenaz üzərində daha təsirli bir inhibitor olduğunu göstərən sübutlar var. Parasetamol analjezik və qızdırmasalıcı xüsusiyyətlərə malikdir, lakin yalnız zəif antiinflamatuar xüsusiyyətlərə malikdir.
Bu, iltihablı toxumaların digər toxumalara nisbətən daha yüksək səviyyədə hüceyrə peroksidləri ehtiva etməsi ilə izah edilə bilər və bu hüceyrə peroksidləri parasetamolun siklooksigenazanı maneə törətməsinə mane olur.

Mənbələr:

Parasetamol

  • Wikipediahttps://tr.wikipedia.org
  • The Royal Children’s Hospitalhttps://www.rch.org.au
  • Ordu Sevgi Hastanesihttps://www.ordusevgi.com

Əlaqəli yazılar

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Umumi

Paracetamol Uşaq Dozası Nə Qədər Olmalıdır?

Parasetamol (asetaminofen və ya para -hidroksiasetanilid) qızdırma və yüngül və orta dərəcəli ağrıları müalicə etmək üçün istifadə edilən qeyri-opioid analjezik və qızdırmasalıcı agentdir. Bu, reseptsiz satılan ümumi bir dərmandır və ümumi marka adlarına Tylenol və Panadol daxildir.

Standart dozada parasetamol bədən istiliyini yalnız bir qədər azaldır. Parasetamol kəskin yüngül miqrendə ağrıları aradan qaldıra bilər, lakin epizodik gərginlik tipli baş ağrılarında yalnız yüngül relyef təmin edir. Parasetamol əməliyyatdan sonrakı ağrılarda da təsirlidir. Qısa müddətdə parasetamol göstərişlərə uyğun istifadə edildikdə təhlükəsiz və effektivdir.

Paracetamol Uşaqlar üçün Necə və Nə üçün İstifadə olunur?

Uşaqlarda yüngül və orta dərəcəli ağrıların və qızdırmaların simptomatik müalicəsi üçün göstərilir.

3 aydan kiçik uşaqlar: 2-ci ayda peyvənddən sonra qızdırması olan körpələr üçün 2,5 ml (1/2 qaşıq) doza uyğun gəlir. İki aydan kiçik körpələrdə istifadə edilməməlidir.
Bu pediatrik dozalar gündə 4 dəfə təkrarlana bilər, hər doza arasında 4 saat və ya daha çox vaxt qalır.
Maksimum gündəlik doza 10-15 mq/kq bölünmüş dozalarda 60 mq/kq təşkil edir.

Körpələrə Doza Miqdarı


3-6 aylıq körpələrdə 2.5 ml 6 saatda bir
6-24 aylıq körpələrdə 5 ml 6 saatda bir
2-4 aylıq körpələrdə 7.5 ml 6 saatda bir
4-6 aylıq körpələrdə 10 ml 6 saatda bir

Xüsusi istifadə xəbərdarlıqları və ehtiyat tədbirləri

Anemiya, ağciyər, qaraciyər və böyrək funksiyası pozulmuş xəstələrdə həkim nəzarəti altında ehtiyatla istifadə edilməlidir. Əvvəllər qaraciyər xəstəliyi olan xəstələr üçün, yüksək dozada və ya uzunmüddətli terapiya zamanı vaxtaşırı
Qaraciyər funksiyası testləri lazım ola bilər. Böyrək çatışmazlığı halında (kreatinin klirensi < 10 ml/dəq) həkim parasetamolun istifadəsinin fayda/risk nisbətini diqqətlə qiymətləndirməlidir.
Parasetamoldan ilk dəfə istifadə edən və ya əvvəllər istifadə etmiş şəxslərdə ilk doza və ya təkrar istifadə dozaları zamanı dəri qızartıları, səpgilər və ya dəri reaksiyaları baş verə bilər. Bu vəziyyətdə həkimə müraciət etmək, dərmandan istifadəni dayandırmaq və alternativ müalicəyə keçmək lazımdır. Parasetamol ilə dəri reaksiyası olan şəxs bu dərmanı və ya tərkibində parasetamol olan hər hansı digər dərmanı təkrar istifadə etməməlidir. Bu vəziyyətə Stiven Conson Sindromu (SJS), zəhərli epidermal nekroliz (TEN) kimi ciddi və potensial ölümcül şərtlər daxildir.
Kəskin ümumiləşdirilmiş ekzantematöz püstüloz (AGEP) daxil olmaqla dəri reaksiyalarına səbəb ola bilər.
Doza düzəliş edilməli və xəstə davamlı olaraq monitorinq edilməlidir.
Xroniki istifadədə gündəlik dozalarda və kəskin yüksək dozalarda qaraciyərin zədələnməsinə səbəb ola bilər.

Hamiləlik dövründə Paracetamolun istifadəsi

Hamiləlik dövründə A-PER-in təhlükəsizliyi müəyyən edilməmişdir. Parasetamol plasentadan keçir və ana konsentrasiyasına bənzər bir fetal konsentrasiyaya çatır. Bununla belə, insan hamiləliyində parasetamolun təhlükəsizliyinə dair epidemioloji sübutlar mövcuddur.
Məsələn, gələcək ananın parasetamolun qısa müddətli istifadəsi teratogen təsir göstərməmişdir.
Parasetamolun hamiləlik dövründə məruz qalması ilə bağlı adekvat klinik məlumat yoxdur.
Heyvan tədqiqatları hamiləlik/embrion/dölün inkişafı/doğuş və ya postnatal inkişafla bağlı birbaşa və ya dolayı zərərli təsirləri göstərmir.

Laktasiya dövrü Paracetamolun istifadəsi

Parasetamol ana südünə keçir (650 mq oral qəbulun 1%-dən az). Bununla belə, ana südü ilə qidalanan ana tərəfindən terapevtik dozalarda istifadənin körpə üçün risk yaratması gözlənilmir.

Farmakodinamik xassələri

Farmakoterapevtik qrupu: Analjeziklər
ATC kodu: N02BE01

Parasetamol analjezik və antipiretikdir. Parasetamolun terapevtik təsirinin siklooksigenaza fermentinin inhibəsi nəticəsində prostaglandin sintezinin ləngiməsi ilə əlaqədar olduğu düşünülür.

Parasetamolun periferik siklooksigenaza nisbətən mərkəzi siklooksigenaza təsiri:
Onun siklooksigenaz üzərində daha təsirli bir inhibitor olduğunu göstərən sübutlar var. Parasetamol analjezik və qızdırmasalıcı xüsusiyyətlərə malikdir, lakin yalnız zəif antiinflamatuar xüsusiyyətlərə malikdir.
Bu, iltihablı toxumaların digər toxumalara nisbətən daha yüksək səviyyədə hüceyrə peroksidləri ehtiva etməsi ilə izah edilə bilər və bu hüceyrə peroksidləri parasetamolun siklooksigenazanı maneə törətməsinə mane olur.

Mənbələr:

Parasetamol

  • Wikipediahttps://tr.wikipedia.org
  • The Royal Children’s Hospitalhttps://www.rch.org.au
  • Ordu Sevgi Hastanesihttps://www.ordusevgi.com

Əlaqəli yazılar

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